| abstract |
The invention provides a method for establishing a neuropsychiatric disease animal model of a non-human mammal and application thereof, in particular to a method for preparing the neuropsychiatric disease animal model of the non-human mammal, which comprises the following steps: (a) providing a non-human mammal cell, and inactivating a Gle gene in the cell to obtain a non-human mammal cell with the Gle gene inactivated; (b) preparing a Glce gene inactivated neuropsychiatric disease animal model by using the Glce gene inactivated cells obtained in the step (a). The animal model is an effective animal model for the neuropsychiatric diseases, can be used for researching the neuropsychiatric diseases such as schizophrenia, manic depression, anxiety, phobia, autism spectrum disorder, stroke, senile dementia and the like, and can be used for screening and testing specific medicines. |