http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107759532-B
Outgoing Links
Predicate | Object |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
filingDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-107759532-B |
titleOfInvention | Benzoxazole-2-ethyl oxime derivative, and preparation method and application thereof |
abstract | The invention provides a benzoxazole-2-ethyl oxime derivative as shown in a formula (I) or a formula (II); wherein, X 1 And X 2 Each independently selected from NH or O; r 1 And R 3 Each independently selected from H, F, Br or Cl; r 2 Selected from C1-C10 alkyl, substituted C1-C10 alkyl, phenyl or substituted phenyl; the substituent of the substituted C1-C10 alkyl is selected from phenyl or halogen. Compared with the prior art, the benzoxazole-2-ethyl oxime derivative shown in the formula (I) or the formula (II) provided by the invention can obviously reduce the ankle swelling degree and the serum uric acid level of a rat with acute gouty arthritis at a medium-high dose, has good NLRP3 and TLR4 double inhibitory activity, has a higher effect than that of positive control dexamethasone, can be used for preparing a medicine for treating hyperuricemia or acute gouty arthritis, and has small side effect and high safety. |
priorityDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 152.