http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107759532-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f68ddaa0ddd894016af217422d657c22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52ad2b4451a3b81d1c064e70eab49e86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34e208ebe657fdd286fd0f0987ce838f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a19a7065cee4c12eaf18a36ee848541e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2cf900200e2d2c90cf6904e44c76952 |
| publicationDate | 2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107759532-A |
| titleOfInvention | A kind of benzoxazole-2-ethyl oxime derivative, its preparation method and application |
| abstract | The present invention provides a kind of benzoxazole-2-ethyl oxime derivative, as shown in formula (I) or formula (II); Wherein, X 1 and X 2 are each independently selected from NH or O; R 1 and R3 are each independently selected from H, F, Br or Cl ; R2 is selected from C1～C10 alkyl, substituted C1～C10 alkyl, phenyl or substituted phenyl; the substituted C1～C10 The substituent of the alkyl group is selected from phenyl or halogen. Compared with the prior art, the benzoxazole-2-ethyloxime derivatives shown in the formula (I) or formula (II) provided by the invention can significantly reduce the acute gouty arthritis rat ankle joint Swelling degree and serum uric acid level, it has good dual inhibitory activity of NLRP3 and TLR4 at the same time, the effect is higher than that of positive control dexamethasone, and can be used to prepare medicines for treating hyperuricemia or acute gouty arthritis, with few side effects and high safety . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110885318-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110885318-A |
| priorityDate | 2017-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.