| abstract |
The invention relates to an anti-bioadhesion polyelectrolyte hydrogel, a preparation method and application thereof. One or more polyelectrolyte polymer solutions with opposite charges are uniformly mixed according to the charge ratio of 1:1, the polyelectrolyte polymer with the opposite charges forms hydrogel through a physical crosslinking method or a chemical crosslinking method or a combination method, the positive and negative electricity reach balance, and the formed hydrogel is neutral in electricity. The method for preparing the polyelectrolyte hydrogel is simple and easy to operate, and the prepared hydrogel has good protein adsorption resistance and high water content, does not cause inflammatory reaction in vivo, and is beneficial to mass transfer between a graft and an organism. Therefore, the preparation can be widely applied to the field of biological medicine, such as islet cell wrapping for treating diabetes, and can be used as a drug release carrier, a wound dressing, a tissue repair scaffold material and the like. |