http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107737138-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-32 |
| filingDate | 2017-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107737138-B |
| titleOfInvention | Method for establishing animal model with memory impairment caused by environmental pollutants |
| abstract | The invention belongs to the technical field of biology, and discloses a method for establishing an animal model with memory impairment caused by environmental pollutants, wherein the animal model establishing process takes 5 weeks, the first 3 weeks are low-dose administration periods, the 4 th week is a high-dose administration period, and the 5 th week is a natural growth period; wherein the low dose administration period comprises 7 days as a cycle operation period, and the cycle is 3 times; the high dose period amounted to 7 days; during the establishment of the animal model, water and food are taken freely. The invention takes a low-pressure oxygen environment, a manganese sulfate solution and a beta-amyloid liquid compound factor as environmental pollutants, adopts a progressive administration mode, gradually induces the brain memory neuron area (hippocampal area) lesion of a rat through the accumulation action of the environment and medicines, establishes a stable memory damage rat model, has diffuse brain lesion of the rat, has good reproducibility, and can well simulate the diffuse brain lesion of the Alzheimer's disease. |
| priorityDate | 2017-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.