http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107737126-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-10 |
| filingDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107737126-B |
| titleOfInvention | Application of coumarin-dithiocarbamate derivative in pharmacy |
| abstract | The invention discloses an application of coumarin-dithiocarbamate derivatives in pharmacy, wherein the related derivatives are synthesized according to the following steps: 1) putting resorcinol and ethyl acetoacetate in a first organic solvent to react by taking concentrated sulfuric acid as a catalyst to obtain an intermediate 2; 2) putting the intermediate 2 and dibromoalkane into a second organic solvent, and reacting under the condition that the pH value is more than or equal to 8 to obtain an intermediateA body 3; 3) and (3) putting the intermediate 3, carbon disulfide and secondary amine into a third organic solvent, and reacting under the condition that the pH value is more than or equal to 8 to obtain a corresponding target compound. The experiments of the applicant show that the coumarin-dithiocarbamate derivative shows good selective acetylcholinesterase inhibition activity and A beta resistance 1‑42 The self-aggregation activity and the blood brain barrier permeability are realized, part of compounds have low toxicity to nerve cells, can penetrate the blood brain barrier and show ideal low toxicity or no toxicity, and have good application prospect in the aspect of treating AD and other diseases. |
| priorityDate | 2017-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 158.