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filingDate 2017-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107723207-B
titleOfInvention A chip for separating and capturing cells and its application in tumor cell sorting
abstract The invention relates to the field of biotechnology, in particular to an integrated chip for separating and capturing cells in one step. The integrated chip includes a cell enrichment area, a cell separation area and a cell capture area. One end of the cell enrichment area is provided with an inlet, and the other end is provided with an entrance. There is a waste liquid outlet and an enrichment liquid outlet; one end of the cell separation zone has a buffer inlet and an enrichment liquid inlet communicated with the enrichment liquid outlet, and the other end has an outlet; one end of the cell capture zone has an inlet communicated with the cell separation zone outlet , the other end has a separation liquid outlet; the cell liquid to be separated enters the cell enrichment area to increase the concentration of target cells in the cell liquid; the enrichment liquid and buffer flowing out from the enrichment area flow into the cell separation area together, and the cells are sized according to their size. Size is separated; cells are then captured in the cell capture zone. Compared with the prior art, the present invention can simultaneously achieve high-efficiency, high-purity, and high-activity separation of target cells from the cell fluid to be treated, and simultaneously achieve in-situ capture of target cells in a chip.
priorityDate 2017-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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