http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107722035-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca5765144d5946338fdb419012358cb5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2017-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29bd7887dcadcc964bd7035dd01b19fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63cd6674132e5d1abe9473b847989a2f |
| publicationDate | 2018-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107722035-A |
| titleOfInvention | A class of artemisinin-piperazine derivatives and its preparation method and application in the preparation of anti-liver cancer drugs |
| abstract | The invention discloses a class of artemisinin-piperazine derivatives, a preparation method thereof and the application of the derivatives in the preparation of anti-liver cancer drugs. The method uses triethylamine as an acid-binding agent to prepare artemisinin-piperazine derivatives through a "one-pot method". The reaction conditions are mild, the operation is simple, and the yield is good. In addition, the prepared derivatives have obvious inhibitory effect on human liver cancer SMMC‑7721 cells in vitro, which is equivalent to the inhibitory effect of vincristine, a first-line anti-hepatic cancer clinical chemotherapy drug. The present invention provides a feasible strategy for the application of artemisinin-piperazine derivatives in the preparation of anti-liver cancer drugs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112707917-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110922414-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114621161-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114621161-A |
| priorityDate | 2017-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.