| abstract |
The invention provides a preparation method of myricetin derivative and its application in treating colitis, preventing and treating cancer transformation of colitis and treating colorectal cancer. Pharmacological experiments prove that the above-mentioned myricetin derivatives have biological activities of significantly inhibiting colitis, preventing and treating cancer transformation of colitis and treating colorectal cancer. The present invention also provides the use of a myricetin derivative in the preparation of a composition for regulating the activity of endoplasmic reticulum stress signal molecules. The invention provides a medicine combination. The myricetin derivatives provided by the invention have good water solubility, and have the effects of treating colitis, preventing and treating colitis cancer transformation and treating colorectal cancer; the invention provides a preparation method of the myricetin derivatives, which can The easy-to-obtain myricetin is used as the starting material, which not only has low cost, but also has high yield and high product purity, which can realize large-scale industrial production, and has great market value and broad economic prospects. |