| abstract |
The invention discloses the new application of the carboxylate of 4 carbonyl of (3,4 dimethoxy phenyl) 3 methyl of phenethyl 6,4,5,6,7 tetrahydrochysene 1H indoles 2.Specifically, phenethyl 6 (3 in the present invention, 4 dimethoxy phenyls) 3 methyl, 4 carbonyl 4,5,6, the carboxylate of 7 tetrahydrochysene 1H indoles 2 possesses the function of AKR1B10 inhibitor, while has weaker inhibitory activity to AKR1B1, can be used for preparing the selective cancer therapy drug related to AKR1B10. |