http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107709561-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0016 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107709561-B |
| titleOfInvention | Modified siRNA and pharmaceutical composition containing same |
| abstract | The present invention provides a modified siRNA for inhibiting the expression of RecQL1 helicase gene, RecQL1 gene expression inhibitor and cell death inducer containing the modified siRNA, and a pharmaceutical composition for treating cancer containing the modified siRNA. Specifically, the present invention provides a modified siRNA, an inhibitor of RecQL1 gene expression and a cell death inducer containing the modified siRNA, and a pharmaceutical composition for treating cancer containing the modified siRNA, as shown below: the modified siRNA is double-stranded modified siRNA comprising a sense strand comprising a base sequence shown in SEQ ID NO. 1 and an antisense strand comprising a base sequence shown in SEQ ID NO. 2 and targeting a RecQL1 helicase gene, wherein the sense strand comprises 2 '-substituted nucleotides at positions 2, 3, 4 and 13 of the base sequence shown in SEQ ID NO. 1, the sense strand further comprises 2' -substituted nucleotides at one or more positions selected from the group consisting of positions 12, 14, 17, 18 and 19 of the base sequence shown in SEQ ID NO. 1, and the 2 'position of the 2' -substituted nucleotide is-R 1 、‑OR 1 、‑R 2 OR 1 、‑OR 2 OR 1 or-R 3 OR 2 OR 1 Wherein R is 1 Is C 1‑4 Hydrocarbyl radical, R 2 And R 3 Independently is C 1‑3 Alkylene groups. |
| priorityDate | 2015-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.