http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107698607-A

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filingDate 2017-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2db850c7e772ec1cade17282bc9f72ca
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publicationDate 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107698607-A
titleOfInvention Comprehensive Recovery Method of Active Components in Enzymatic Synthesis of Ampicillin Crystallization Mother Liquor
abstract The invention belongs to the technical field of pharmacy, and relates to a method for comprehensively recovering active ingredients in ampicillin crystallization mother liquor synthesized by enzymatic method. The present invention adopts the separation mode of macroporous adsorption resin to realize the separation of D-phenylglycine and ampicillin, 6-APA and D-phenylglycine methyl ester, D-phenylglycine is not adsorbed by resin, enters the adsorption residual liquid, and the adsorption residual After electrodialysis, reverse osmosis concentration, and crystallization, high-quality D-phenylglycine is recovered; and ampicillin, 6-APA and D-phenylglycine methyl ester adsorbed on the resin are analyzed and then concentrated by nanofiltration. The obtained nanofiltration concentrate can be directly used as the reaction bottom water in the ampicillin enzymatic synthesis process and then recovered and used mechanically. The present invention comprehensively recovers the active ingredients D-phenylglycine, ampicillin, 6-APA and D-phenylglycine methyl ester in the enzymatic ampicillin crystallization mother liquor, creates economic benefits, reduces the discharge of high-concentration waste water at the same time, and realizes Environmentally friendly, clean and green production.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111393315-B
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priorityDate 2017-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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