http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107698565-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_750e403b156325c34753111506716a46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2017-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea4c19274f7ce14c6329c3cb24677546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0be0637f7e16d8dd84e257776abf518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1a166ca40b28d2bff3f9ba44dcccc42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e6e7f47cd18dfba9374df98626877e9 |
| publicationDate | 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107698565-A |
| titleOfInvention | A kind of hydrazone compounds of pyrimidine ring containing indoles and its production and use |
| abstract | The invention discloses a kind of hydrazone compounds of pyrimidine ring containing indoles, described compound structure formula is： Present invention also offers the preparation method and applications of such a hydrazone compounds of pyrimidine ring containing indoles, the present invention passes through two-step reaction synthetic intermediate 3 using indoles, cyanoacetic acid and DMF DMA as raw material（Dimethylamino）‑2‑（The carbonyl of 1H indoles 3）Acrylonitrile, then reduce by cyclization, nitro with nitroguanidine to obtain the diazanyl 4 of key intermediate 2（The carbonyl of 1H indoles 3）The formonitrile HCN of pyrimidine 5, then obtain target product from different fragrant aldehyde reactions；Such compound two class active structures containing indoles pyrimidine ring and acylhydrazone simultaneously, therefore with stronger potential source biomolecule activity, antitumor activity in vitro shows that the compound has stronger inhibitory action to test tumour cell, antineoplastic or lead compound can be used as further to develop. |
| priorityDate | 2017-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.