| abstract |
The invention relates to a halogen-substituted heterocyclic compound, and provides a novel α-position halogen-substituted thiophene compound or a pharmaceutically acceptable salt thereof, which has strong LPA receptor antagonism and can be used in medicine. A compound represented by general formula (I) or a salt thereof, [wherein, A represents a benzene ring, a thiophene ring or an isothiazole ring; R 1 is the same or different, and represents a halogen atom or a C 1 -C 3 alkyl group; R 2 represents a hydrogen atom or a C 1 ‑C 6 alkyl group; p represents an integer of 0 to 5; V represents CR 3 (in the formula, R 3 represents a hydrogen atom, an amino group, a nitro group or a C 1 ‑C 3 alkoxy group) or Nitrogen atom; X represents a halogen atom. ]. |