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filingDate 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107693846-B
titleOfInvention A kind of bionical vascularization soft tissue and preparation method thereof with multilayer blood vessel structure
abstract The invention discloses a kind of bionical vascularization soft tissue and preparation method thereof with multilayer blood vessel structure.The preparation method includes the following steps: to obtain the sacrificial mold with branch structure by injection molding or 3D printing method;On the surface of expendable film, the polymer solution of coating or spraying containing pore-foaming agent obtains thin polymer film;The expendable film and pore-foaming agent for removing the structure through above-mentioned processing obtain the class vascular access structure with surface pore;The perfusion plantation endothelial cell in the channel of class vascular access structure;Smooth muscle cell or fibroblast are planted in the surface pore of class vascular access structure;Class vascular access structure through above-mentioned processing is placed in mold, the hydrogel solution containing parenchyma is added, moldings formed therefrom obtains bionical vascularization soft tissue.The method of the present invention can construct bionical blood vessel with multi-layer structure in artificial organ.
priorityDate 2017-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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