http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107686495-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107686495-B |
| titleOfInvention | A kind of synthetic method of Fondaparinux sodium intermediate |
| abstract | The invention discloses a kind of synthetic methods of Fondaparinux sodium intermediate shown in formula 1; the synthetic method includes using 2 compound represented of formula and benzaldehyde as reaction raw materials; the acetal protection reaction and de- diacetyl group is set to react in organic solvent, the step of Fondaparinux sodium intermediate shown in formula 1 is prepared in next step in mixed acid catalyst; wherein; the mixed acid is made of the concentrated sulfuric acid and p-methyl benzenesulfonic acid 1 ︰ 0.1~5 in mass ratio, and wherein the concentrated sulfuric acid is the aqueous sulfuric acid that mass fraction is 70~98%；The organic solvent includes 5%~15% toluene for accounting for the organic solvent volume；Wherein, the volume ratio of the water in control starting reaction system and the organic solvent is 0.005~0.04 ︰ 1；The present invention has high conversion rate, reaction speed fast, easy to operate, the advantages of being suitable for mass producing. |
| priorityDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.