http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107686495-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0352f26a7cb1dc2b098f3ca5decc839f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e0016cc810ae8294397c81001c50d08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_841d0d794db26c6eac417b0144a98bdd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_731fd662433a50ba1bfee8c9ba4eed4e |
| publicationDate | 2018-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107686495-A |
| titleOfInvention | A kind of synthetic method of Fondaparinux sodium intermediate |
| abstract | The invention discloses a kind of synthetic method of the Fondaparinux sodium intermediate shown in formula 1; the synthetic method is included using the compound shown in formula 2 and benzaldehyde as reaction raw materials; make acetal protection reaction and the reaction of de- diacetyl group in organic solvent, the Fondaparinux sodium intermediate shown in formula 1 is prepared in next step in mixed acid catalyst the step of; wherein; the mixed acid is made up of the concentrated sulfuric acid and p-methyl benzenesulfonic acid 1 ︰ 0.1~5 in mass ratio, and wherein the concentrated sulfuric acid is the aqueous sulfuric acid that mass fraction is 70~98%；Described organic solvent includes 5%~15% toluene for accounting for the organic solvent volume；Wherein, the volume ratio for controlling water and the organic solvent in initial action system is 0.005~0.04 ︰ 1；The present invention has the advantages of high conversion rate, reaction speed are fast, simple to operate, suitable for large-scale production. |
| priorityDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.