| abstract |
The invention provides an intermediate drug with synergistic anticancer activity, a polyethylene glycol-coupled synergistic anticancer drug, a preparation method and application thereof, and belongs to the field of cancer treatment. The general structural formula of the intermediate drug with synergistic anticancer activity is The general structural formula of the polyethylene glycol coupling synergistic anticancer drug is These two types of drugs can realize the combination of multiple anticancer drugs, avoid the toxic reactions caused by the interaction between drugs and pharmacokinetics when taking multiple anticancer drugs alone, and help to overcome cancer. The multidrug resistance has a synergistic effect, can be used to prepare anticancer drugs, and has great clinical value and broad market prospects. |