| abstract |
The invention discloses a preparation method and application of a reduction-sensitive drug delivery system with high drug loading, and belongs to the technical field of biomedicine and nanomedicine. The key points of the technical scheme of the present invention are: 2,2-dihydroxyethyl disulfide is bonded to camptothecin through a carbonate bond to construct a reduction-sensitive camptothecin dimer, and then the camptothecin The dimer is encapsulated into the amphiphilic block copolymer polyethylene glycol-polycaprolactone to obtain a high-loading reduction-sensitive drug delivery system, wherein the structural formula of the camptothecin dimer is: The invention also specifically discloses the application of the reduction-sensitive drug delivery system with high drug loading in the preparation of slow-release and targeted anticancer drugs. Compared with the camptothecin delivery system, the drug delivery system of the present invention has its drug loading increased from 1% to 12.6%, and the drug delivery system has reduction sensitivity, good biocompatibility and the ability to inhibit tumor cell proliferation. ability. |