http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107667107-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
filingDate | 2016-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-107667107-B |
titleOfInvention | Ethynyl derivatives |
abstract | The present invention relates to compounds of formula (I), wherein R 1 is hydrogen, F or Cl; L is a bond or lower alkylene; R 2 is -(CH 2 ) n O-lower alkyl, lower alkane substituted by halogen base, -(CH 2 ) n C(O)O-lower alkyl, phenyl substituted by lower alkyl or halogen, or selected from pyridyl, pyrimidinyl, pyridazinyl, thiazolyl, imidazolyl, pyridyl 5- or 6-membered heteroaryl of azolyl or triazolyl, optionally by lower alkyl, halogen, lower alkoxy, =O, benzyloxy, cycloalkyloxy, hydroxy, cyano, halogen-substituted lower alkyl or -(CH 2 ) n O-lower alkyl; n is 1, 2 or 3; R 3 is hydrogen, lower alkyl or -(CH 2 ) n O - lower alkyl; R 4 is phenyl, pyridyl or pyrimidinyl, which is optionally substituted by F; Y is CF or CCl; or relates to its pharmaceutically acceptable salt or acid addition salt, racemic mixture, or other The corresponding enantiomers and/or optical isomers and/or stereoisomers. The compounds can be used to treat Parkinson's disease, anxiety, vomiting, obsessive-compulsive disorder, autism, neuroprotection, cancer, depression and type 2 diabetes. |
priorityDate | 2015-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 443.