| abstract |
The invention discloses a preparation method of an intermediate of niraparib, as shown in the following formula, which comprises the following steps: using (S)-oxazolidinone and p-bromophenylacetic acid as starting materials, performing amide condensation, Michael addition, reduction of lipids and amides, synthesis of sulfonyl esters, ammoniation to form rings, and reaction with organic acids to form salts. The invention also discloses a preparation method of niraparib and an intermediate compound thereof. The preparation method of the invention has low cost, easy-to-obtain raw materials and high yield, and is suitable for industrialized production. |