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filingDate 2017-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107652967-B
titleOfInvention Auto-fluorescent polyacrylamide nano particle and preparation method and application thereof
abstract The invention discloses an autofluorescence polyacrylamide nano particle and a preparation method and application thereof. The autofluorescence polyacrylamide nano particles prepared by the invention can be efficiently internalized into cells to mark the cells, the autofluorescence is bright and stable in vitro and in vivo for a long time, the autofluorescence has excellent visible fluorescence and near infrared fluorescence properties, and the autofluorescence nano particles have the advantages of uniform particle size, good monodispersity, positive charge, strong water absorption, good hydrophilicity and excellent biocompatibility in cells and animals. Meanwhile, the preparation method is simple and convenient, the cost is low, the raw material source is wide, and the prepared auto-fluorescence polyacrylamide nanoparticles can be used in the fields of biological detection, cell marking, animal imaging, drug delivery, gene therapy and the like and have important application value.
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