http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107652271-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2017-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107652271-B |
| titleOfInvention | Preparation method of topiroxostat crystal form I |
| abstract | The invention relates to a preparation method of topiroxostat crystal form I, and belongs to the technical field of medicines. The invention provides a Topiroxostat crystal form I suitable for preparing a preparation, and simultaneously provides an environment-friendly preparation method of the Topiroxostat crystal form I suitable for industrial operation. According to the technical scheme, 4-methyl formate pyridine is used as an initial raw material, and the crystal form I of topiroxostat is prepared through the steps of introducing an amide group, dehydrating, nucleophilic substitution, nucleophilic addition, condensation salifying and the like. The technical scheme of the invention reduces the use of solvent and the consumption of energy through the use of a telescoping process. Meanwhile, through reasonable salification, the generation of genotoxic impurities is avoided. |
| priorityDate | 2017-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.