http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107638612-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-04 |
| filingDate | 2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107638612-B |
| titleOfInvention | Anticoagulation antibacterial indwelling needle cannula and preparation method thereof |
| abstract | The invention provides an anticoagulant antibacterial indwelling needle cannula and a preparation method thereof, wherein the anticoagulant antibacterial indwelling needle cannula comprises an indwelling needle cannula and an anticoagulant antibacterial coating grafted to the indwelling needle cannula through photoinitiation; the coating comprises heparin sodium and hydrogen-extraction type quaternary ammonium salt with a structure shown in a formula I. The hydrogen extraction type quaternary ammonium salt has hydrogen extraction and recombination reactions with the surface of the matrix of the indwelling needle cannula and heparin molecules, so that the coating has high adhesion, good adhesion stability, strong universality and practicability; the anti-coagulation and anti-bacterial agent has non-release type anti-coagulation and anti-bacterial effects, does not cause dissociation and falling of coating components in the processes of cannula penetration, infusion, blood flow flushing and the like, has lasting anti-coagulation and anti-bacterial effects, and avoids the risk of causing systemic toxicity after the leached quaternary ammonium salt enters the vein. Formula I; r is selected from Or R 1 And R 2 Independently selected from H or C1-C4 alkyl; r 3 Selected from C8-C16 alkyl; x ‑ Selected from Cl ‑ 、Br ‑ Or I ‑ 。 |
| priorityDate | 2017-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.