http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107628999-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| filingDate | 2017-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107628999-B |
| titleOfInvention | The preparation method of Aripiprazole dodecylate |
| abstract | The present invention provides a kind of preparation methods of Aripiprazole dodecylate, include the following steps: S1 in amide solvent, compound (II) reacts to obtain compound (III) in the presence of acid binding agent with halogenated silanes, wherein R 1 , R 2 , R 3 For alkyl；S2 is in alcohols solvent, and for compound (III) with polyformaldehyde reaction in the presence of acid binding agent, treated intermediate product, with dodecane acyl chloride reaction in the presence of acid binding agent, generates compound (IV in furans or amide solvent；S3 compound (IV) sloughs silicon ether with tetrabutyl ammonium fluoride in THF solvent and obtains compound (V)；The in the mixed solvent that S4 is mixed in one of acetone solvent, amide solvent, nitrile solvents solvent multi-solvents, compound (V) and the bromo- 4- chlorobutane of 1- and 1- (2,3- dichlorophenyl) piperazine reacts in the presence of acid binding agent, sodium iodide, prepare Aripiprazole dodecylate.This method simple process, product yield and purity are significantly increased and can reappear, and are convenient for industrialized production. |
| priorityDate | 2017-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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