http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107628947-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-307 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-76 |
| filingDate | 2017-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_736b452e44f33fd38306457b33bd39e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92c87856ef2a676ec2b9282b3c896295 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b90931dd1a2b4329c75d3027f30a04c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d44cedba5c6bfc86d34382e3c5043121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edccaa40295fbdf1d0ac3f22c74feb68 |
| publicationDate | 2018-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107628947-A |
| titleOfInvention | A kind of preparation method of pemetrexed disodium key intermediate |
| abstract | The invention discloses a preparation method of the key intermediate (I) of pemetrexed disodium. The method uses toluene and succinic anhydride as raw materials, and adopts classic Friedel-Crafts acylation and esterification reactions to obtain 3‑(4‑methyl Methyl phenyl)-4-oxobutyrate, catalyzed by N-hydroxyphthalimide (NHPI) and cobalt acetate, oxygen or air oxidation to give 4-(4-methoxy-4 -Oxobutylcarbonyl) benzoic acid, the oxidation product undergoes selective reduction, selective oxidation, esterification and bromination reaction to obtain 4-(3-bromo-4-oxobutyl) methyl benzoate. The raw materials adopted in the method of the invention are cheap and easy to obtain, the reaction conditions are mild, the treatment is simple, the product yield is high and the purity is high, and the method is suitable for industrialized production. |
| priorityDate | 2017-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.