http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107624114-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N5-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 |
| filingDate | 2016-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107624114-B |
| titleOfInvention | Low molecular weight derivatives of carboxamide halogenated porphyrins, namely chlorins and bacteriochlorins, and uses thereof |
| abstract | The present invention relates to carboxamide halogenated porphyrin derivatives, in particular bacteriochlorins or chlorins, of formula: formula (I) wherein: represents a carbon-carbon single bond or a carbon-carbon double bond, with the proviso that at least one represents a carbon-carbon single bond; y is 1 ，Y 2 Each independently selected from hydrogen, halogenated alkyl or halogenated cycloalkyl groups having 6 or less carbon atoms, or halogenated phenyl groups, wherein the halogen is independently selected from F, Cl and Br, provided that at least one position of the alkyl, cycloalkyl or phenyl groups is halogenated, and provided that Y is 1 、Y 2 At least one of which is not hydrogen; r 1 Selected from H, I, Cl, Br or-CONR 'R' wherein R 'and R' are independently selected from hydrogen, alkyl groups having 6 or fewer carbon atoms,cyclopropyl, cyclobutyl, cyclopentyl, alcohol, primary amine, secondary amine, tertiary amine, positively charged quaternary amine, carboxylic acid, ether or ester, or a pharmaceutically acceptable salt thereof. The invention also relates to the use of the above carboxamide halogenated porphyrin derivatives, in particular bacteriochlorin or chlorin of formula (I) or a pharmaceutically acceptable salt thereof, in photodynamic therapy, wherein said derivatives are capable of detecting and displaying the presence of hyperproliferative disorders and of treating them in the presence of suitable light. The invention also describes pharmaceutical compositions comprising one or more carboxamide halogenated porphyrin derivatives of formula (I), in particular bacteriochlorins or chlorins or pharmaceutically acceptable salts thereof, for use in the treatment of cancer and/or microbial and/or viral infections in humans or animals. |
| priorityDate | 2015-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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