http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107576734-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2017-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107576734-B |
| titleOfInvention | A kind of detection method of faropenem impurity |
| abstract | The invention discloses a method for detecting impurities of faropenem, which comprises the following steps: the stationary phase of a high performance liquid chromatograph is 100% porous graphite, and the mobile phase is 10mmol/l ammonium formate aqueous solution-methanol=45:55～55: 45. The column temperature is 30℃～40℃, and the detection wavelength is 218nm～222nm. Inject 20µl of the reference solution, the test solution and the blank solution into the liquid chromatograph, and record the chromatogram. Calculate the concentration of the reference solution as X and the corresponding peak area as Y, and perform linear fitting to obtain a linear regression equation. The linear range of intermediate C is 0.38~5.25 μg/ml, and the linear range of faropenem is 0.38~ 28.92 μg/ml. The present invention uses high performance liquid chromatography to separate the intermediate C in the previous step of faropenem, has high separation efficiency, fast analysis speed and high detection sensitivity, and can better control the quality of the faropenem by detecting the content of the intermediate C in the faropenem . |
| priorityDate | 2017-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.