| abstract |
The invention provides a targeted drug-loaded polymer, which has the structure shown in formula (I). The targeted drug-loaded polymer provided by the present invention has a targeting group, which can be targeted to the tumor site and enriched. When the responsive prodrug is combined with the targeted polymer, the drug concentration at the tumor site can be increased; secondly, Responsive prodrugs can release antitumor drugs responsively at tumor sites, and different acidity responsiveness can be regulated by changing the structure of anhydrides, resulting in different degrees of cleavage. Again, the present invention regulates the particle size and drug loading rate of nanoparticles by providing targeted RGD-polyethylene glycol-b-poly(L-lysine) with different block lengths. |