| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68f068d5cd5a8559000752c8796028c9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate |
2017-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fb8957a21d6e317ab4551701277ac12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c602883c9b54640876604870147c96fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61a674c9d980144be7e6074207e33086 |
| publicationDate |
2018-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107540685-A |
| titleOfInvention |
A kind of preparation method of Sotagliflozin and its intermediate |
| abstract |
The preparation method of Sotagliflozin provided by the present invention is to improve the structure of L-xylose derivative 1, protect the hydroxyl group with benzyl or PMB group to obtain compound 2 or obtain L-xylose derivative 1A through a series of derivatization reactions Compound 2, it is optimized with the Grignard docking reaction conditions of 4-halo-1-chloro-2-(4-ethoxybenzyl)benzene compound 3, and the reaction yield is increased to more than 85%, avoiding the Using too much Grignard reagent or lithium reagent reduces material consumption and improves route efficiency. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019166958-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110818722-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110818722-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108912080-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108912080-B |
| priorityDate |
2017-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |