http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107540627-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D273-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2017-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107540627-B |
| titleOfInvention | Dehydroabietic acid oxadiazine heterocyclic derivatives with antibacterial activity and preparation method and application thereof |
| abstract | The invention discloses dehydroabietic acid oxadiazine heterocyclic derivatives with antibacterial activity, and a preparation method and application thereof. The invention relates to dehydroabietic acid oxadiazine heterocyclic derivatives with a structure shown in a general formula (I) and pharmaceutically acceptable salts thereof: the invention relates to a dehydroabietic acid oxadiazine heterocyclic derivative I-a with a structure shown in a general formula (I) 1 To I-a 9 ，I‑b 1 To I-b 2 The preparation method comprises the following steps: (1) dehydroabietic acid is subjected to thionyl chloride acyl chlorination reaction to obtain dehydroabietyl chloride; (2) reacting dehydroabietyl chloride with phenylhydrazine hydrochloride containing different substituents to obtain a dehydroabietyl phenylhydrazine derivative with the corresponding substituents; (3) and (3) reacting the dehydroabietylphenylhydrazine derivative with chloroacetyl chloride for cyclization to obtain the dehydroabietic acid oxadiazine heterocyclic derivative with the corresponding substituent. The dehydroabietic acid oxadiazine heterocyclic derivative has a strong inhibition effect on bacteria, and has a value in developing antibacterial drugs. |
| priorityDate | 2017-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.