http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107540549-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-757 |
| filingDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107540549-B |
| titleOfInvention | anti-Alzheimer disease compound in secondary metabolites of aspergillus terreus and separation and preparation method thereof |
| abstract | The invention provides a new terpenoid compound with an effect of resisting Alzheimer disease and a separation preparation method thereof, the compound is derived from secondary metabolites of soil Aspergillus terreus, and 3 new compounds are obtained by performing solid fermentation on soil Aspergillus terreus QCX1-1 and separation and purification on industrial alcohol (95% ethanol) extracts of fermentation products of the soil Aspergillus terreus QCX 1-1. A structure of the compound is determined to be a diterpenoid compound by using a plurality of spectrum analysis means and other methods, and the evaluation of the BACE1 inhibitory activity of the 3 new compounds proves that 2 compounds can generate extremely strong inhibitory activity to BACE1 in vivo and in vitro, and can be used as a lead compound for developing medicaments for treating the Alzheimer disease. |
| priorityDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.