| abstract |
The present invention provides chimeric protein, and it includes the multispan transmembrane protein merged with FAS Intracellular domains, wherein the multispan transmembrane protein is combined with extracellular ligand, causes the activation of FAS Intracellular domains.The chimeric protein is used as suicide gene.The present invention also provides the cell for including such chimeric protein, such as T cell, and it is useful in adoptive T cell immunotherapy method. |