http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107523594-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-39 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 |
| filingDate | 2017-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107523594-B |
| titleOfInvention | The synthetic method of clopidogrel and its sulfate |
| abstract | The invention discloses the synthetic methods of a kind of clopidogrel and its sulfate, include the following steps：O-chlorobenzaldehyde, nitrilation sodium, ammonium chloride reaction, 2 amino 2 (2 chlorphenyl) acetonitriles are generated, then generate 2 amino 2 (2 chlorphenyl) acetic acid under the effect of the catalyst, are split, purifying generates S 2 amino 2 (2 chlorphenyl) acetic acid；Methanol is added, reaction generates S 2 amino 2 (2 chlorphenyl) methyl acetate；It reacts, purifies in a solvent with α thiophene ethanol p-methyl benzenesulfonic acid esters, generate S α (2 thiophene ethylamino) 2 (2 chlorphenyl) methyl acetate；2 (2 chlorphenyl) methyl acetates of S α (2 thiophene ethylamino) are reacted with formaldehyde, and purifying obtains clopidogrel.Raw material supply of the present invention is sufficient, at low cost；Easily-controlled reaction conditions, easy to operate, technological process is simple, to equipment without particular/special requirement, is suitable for large-scale production. |
| priorityDate | 2017-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 208.