| abstract |
The invention discloses a kind of pyrroles [2,1 a] morphinane alkaloid, preparation method and medical applications, belong to medicinal chemistry art.The general structure of pyrroles [2,1 a] morphinane alkaloid of the present invention is such as（1）It is shown, R 1 For C 1‑4 Alkyl, C 1‑4 Alkoxy, hydrogen atom, halogen atom；R 2 For C 1‑4 Alkyl, C 1‑4 Alkoxy, hydrogen atom, halogen atom；R 3 For C 1‑4 Alkyl, phenyl or substituted-phenyl, benzyl or substituted benzyl；R 4 For hydrogen, C 1 ‑C 6 Alkyl, phenyl or substituted-phenyl, benzyl or substituted benzyl.The invention also discloses the environment-friendly preparation method thereof of pyrroles [2,1 a] morphinane alkaloid and application of the pharmaceutical composition including them and their salt in antineoplastic is prepared. (1)。 |