http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107522635-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C291-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C291-02 |
| filingDate | 2017-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107522635-B |
| titleOfInvention | N-cyclopropyl nitrone derivatives and preparation method thereof |
| abstract | The invention provides N-cyclopropyl nitrone derivatives and a preparation method thereof, belonging to the technical field of organic synthetic chemistry. The structural formula of the derivative is shown as formula I, wherein in the formula I, R 1 Is aryl, heteroaryl or alkyl, R 2 Is aryl, heteroaryl, hydrogen or alkyl, R 3 Is aryl, heteroaryl or alkyl, R 4 Is aryl, alkyl or hydrogen. The invention also provides a preparation method of the N-cyclopropyl nitrone derivative, which comprises the step of reacting a cyclopropene compound, oxime and a ligand under the action of a copper catalyst and an organic solvent to obtain the N-cyclopropyl nitrone derivative. The preparation method has the advantages of mild reaction conditions, high conversion rate and wide substrate universality. The used catalyst cuprous chloride and the raw material oxime are cheap and easy to obtain, and a simple and efficient way is provided for the synthesis of the ketonitrone which is difficult to prepare at present. |
| priorityDate | 2017-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.