http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107513090-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2017-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107513090-B |
| titleOfInvention | The preparation method of megestrol acetate |
| abstract | The preparation method of megestrol acetate dissolves in raw material in organic solvent using 6- ketone group -17a- acetoxyl group progesterone as raw material, in the presence of triethyl orthoformate, obtains double Betamethasone Ketal structures with ethylene glycol acid catalyzed reaction；Double Betamethasone Ketal structures are dissolved in organic solvent again, carry out grignard reaction with Grignard Reagent, after having reacted under strong acid effect, the hydrolysis of grignard object, while being deprotected, being dehydrated, megestrol acetate crude product is synthesized by two-step reaction；Crude product is laid equal stress on crystallization with active carbon decoloring, obtains megestrol acetate product, HPLC content 99.0~99.5%, 213~220 DEG C of fusing point, two steps synthesize weight total recovery 80~85%.For the present invention with respect to conventional method, synthetic route is short, and technological operation is easy, and production economy environmental protection, synthesis total recovery improves 30% or more than conventional method, and production cost reduces 30-35%；Recycled can be recycled in solvent used in technique, not only economical, but also environmental protection, is very beneficial to industrialized production. |
| priorityDate | 2017-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.