http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107501353-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107501353-B |
| titleOfInvention | A kind of preparation method of Fondaparinux sodium intermediate |
| abstract | The invention discloses a kind of preparation methods of Fondaparinux sodium intermediate shown in formula 1, include the following steps：1) D gluconate dehydratases is made to be condensed 6 compound represented of production；2) 6 compound represented of formula reacts 5 compound represented of production with acetate succinate imide ester under immobilized candida antarctica lipase catalysis；3) 5 compound represented of formula reacts 4 compound represented of production with toluene sulfochloride in the presence of acid binding agent；4) under alkaline condition cyclization occurs successively for 4 compound represented of formula and 3 compound represented of production is reacted in deacetylated protection；5) 3 compound represented of formula reacts 2 compound represented of production with pentaacetylglucose in the presence of Trimethlsilyltriflat；6) 2 compound represented of formula and benzaldehyde, successively occur acetal protection reaction and de- diacetyl group reaction to get；Its preparation process is few, selectivity is good, high conversion rate, easy to operate, is suitable for large-scale production. |
| priorityDate | 2017-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.