http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107501265-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 2017-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107501265-B |
| titleOfInvention | A kind of 7- oxo-diazabicylo [3,2,1] octane derivatives compound and its preparation method and application |
| abstract | The present invention relates to a kind of 7- oxo-diazabicylo [3,2,1] octane derivatives compounds and its preparation method and application, belong to technical field of medicine synthesis.In order to solve the problems, such as it is how to obtain high activity antibacterials, a kind of 7- oxo-diazabicylo [3 is provided, 2,1] octane derivatives compound and preparation method thereof, this method is included in the presence of acid binding agent, IV compound of formula and RH carry out condensation reaction, obtain V compound of intermediate product formula；Above-mentioned RH is selected from substituted or unsubstituted 1H-1,2,3- triazoles or 1H-1,2,4- triazole compounds, and formula VI or VII compound and the corresponding R in type I compound 2 、R 3 And R 4 It corresponds；After adding hydrogen deprotection processing removing benzyl, then, sulfonated or phosphorus acylation reaction obtains type I compound 7- oxo-diazabicylo [3,2,1] octane derivatives compound.Derivative compound of the invention has preferable antibacterial activity, especially has good inhibiting effect effect to pseudomonas aeruginosa and Escherichia coli；And method is easy to operate, mild condition. |
| priorityDate | 2017-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.