http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107501196-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab2594fe9ef0d3cd5223af44df14ffb2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-24 |
| filingDate | 2017-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_501dfe81576984a076eec844beb66f53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e39dc3a52b54be0cd58cb7a9e0f26095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa67b7804177814f4f4bb39ece50b9da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_408af19447d212552c72a9028c7dfd14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5ce7d1abca4af1210bc5f2622f07a8e |
| publicationDate | 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107501196-A |
| titleOfInvention | Intermediates for the preparation of diazepam‑D5 and diazepam‑D8 and methods for their preparation |
| abstract | The invention discloses an intermediate for preparing diazepam-D5 and diazepam-D8 and a preparation method thereof. As a raw material, after reaction with deuterated bromophenyl Grignard reagent, hydrolysis, acylation, cyclization, separation and purification to obtain the intermediate 7-chloro-1,3- for the preparation of diazepam-D5 and diazepam-D8 Dihydro-5-(phenyl-d 5 )-2H-1,4-benzodiazepin-2-one. The process of the present invention has the advantages of mild reaction conditions and simple operation. The deuterated diazepam intermediate prepared by the present invention has high chemical purity, good product quality and good stability, and can be used to prepare diazepam-D 5 standard products. It can also be used to prepare diazepam-D 8 standard and other related deuterium standards. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114031566-A |
| priorityDate | 2017-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.