http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107496996-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2420-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-08 |
| filingDate | 2017-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107496996-B |
| titleOfInvention | A kind of vascular stent loaded with drugs and preparation method thereof |
| abstract | The invention provides a drug-loaded vascular stent, comprising a stent body and a drug coating on the stent. The outer surface of the stent coating is a smooth mirror surface, and the coating extends outward from the surface of the stent body, and sequentially includes: a first coating, The coating carrier is dopamine, on which substance A is grafted; the second coating, the coating carrier is PLGA, and contains the drug B; the third coating; the coating carrier is PLGA, which contains the drugs C and B; wherein, A is Heparin, B is rapamycin, C is curcumin. The present invention also provides a method for preparing the above stent, including methods for stent treatment, freeze-dried product preparation, first coating preparation, second coating preparation and third coating preparation. The advantages of the present invention lie in that the three-layer drug-loading coating, the drug is released layer by layer after stent implantation, according to the order of rapamycin, curcumin and heparin, in line with the occurrence trend of thrombosis and smooth muscle proliferation, and the validity period of the drug is prolonged, It can inhibit the subsequent potential thrombosis and smooth muscle hyperplasia. |
| priorityDate | 2017-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.