http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107496934-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2017-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107496934-B |
| titleOfInvention | Nuclear-targeted anti-tumor nano-drug carrier and preparation method and application thereof |
| abstract | The invention relates to a cell nucleus targeted anti-tumor nano-drug carrier and a preparation method and application thereof, wherein the nano-drug carrier is composed of a polymer micelle NLS-PEG-PASp (BzA) and a pH sensitive negative electric polymer which is constructed on the surface of the polymer micelle through electrostatic interaction, and the pH sensitive negative electric polymer is changed from negative electric to positive electric when the pH is 6.5-6.8; the particle size of the polymer micelle is 20-40 nm, and the particle size of the nano-drug carrier is 100-110 nm. The cell nucleus targeted anti-tumor nano-drug carrier provided by the invention can stably circulate in vivo and is effectively enriched on tumor parts through an EPR effect. When the nano-drug reaches a tumor microenvironment, under the condition that the pH value is 6.5-6.8, the negative electric polymer protective layer compounded on the surface of the polymer micelle is changed from negative electric to positive electric, and then the polymer micelle nano-particle is separated from the surface of the polymer micelle nano-particle with positive electric; the positively charged polymer micelle is favorable for endocytosis of cells, and is finally targeted to the nucleus of a tumor cell under the action of the nuclear localization signal peptide, so that the release of the antitumor drug in the nucleus is realized. |
| priorityDate | 2017-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.