| abstract |
The invention belongs to the field of bone repair materials, and provides a tyramide/bisphosphonate-hyaluronic acid polymer compound, a radionuclide-labeled tyramide/bisphosphonate-hyaluronic acid polymer compound, and a preparation method of the two, comprising: The hydrogel formed on the basis of the two, and the application of the hydrogel in the field of biomaterial in vivo tracking and bone repair. The two hydrogels provided by the present invention, as bone tissue repair materials, show good ability to promote bone repair in vivo, and the radionuclide-labeled hydrogel is a bone tissue repair material that can be traced in vivo. Imaging can not only track the filling effect of the material in vivo, but also deeply understand its degradation process. In particular, the hydrogels labeled with therapeutic nuclides 188 Re and 177 Lu can also have a certain therapeutic effect on bone tissue necrosis, inflammation or carcinogenesis, and have dual functions of in vivo imaging and bone tissue repair. |