| abstract |
The invention discloses a class of pyridotriazole compounds, a preparation method and application thereof. After long-term in-depth research, the inventors have prepared a class of compounds A 01 ~ A 20 with SMO target inhibitory activity, which belong to a class of pyridotriazole compounds. Through molecular docking experiments, it can be seen that the compounds of the present invention can be combined with the target The target protein SMO forms a strong binding effect; and has an excellent inhibitory effect on various tumors, and is expected to be used in the preparation of SMO target inhibitors and anti-tumor drugs. The preparation method of the compound of the present invention has simple process, short time consumption, greatly reduces the cost of medicine, and is suitable for large-scale production. |