| abstract |
The invention discloses a class of LSD1 inhibitors with a 2-phenyl-4-styrylpyridine structure, a preparation method thereof and an application in the preparation of antitumor drugs, belonging to the technical field of medicinal chemistry. Compounds of the present invention have the general formula: In vitro LSD1 enzyme inhibitory activity and antitumor activity experiments have proved that this type of compound has obvious inhibitory effect on tumor cells by inhibiting the activity of LSD1, and can be used as a lead compound for further development and applied to the preparation of antitumor drugs. |