http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107468657-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 |
| filingDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107468657-B |
| titleOfInvention | Cefmetazole sodium pharmaceutical composition for injection |
| abstract | The invention relates to a cefmetazole sodium composition for injection, which contains 99.1-99.75wt% of cefmetazole sodium sterile powder, 0.05-0.1% of sodium salicylate, 0.1-0.5% of glucose and 0.1-0.3% of vitamin C, wherein the cefmetazole sodium sterile powder is amorphous cefmetazole sodium. The invention also relates to the preparation of the amorphous cefmetazole sodium powder for injection, which is characterized in that cefmetazole sodium is heated and dissolved in a proper benign solvent water/N, N-dimethylacetamide mixed solution, and then is sterilized and filtered, the filtrate is dripped into an inert solvent butanone/ethanol mixture at a certain stirring speed and flow rate, and then is cooled, crystallized, filtered and dried to obtain the amorphous cefmetazole sodium sterile powder. The invention provides a preparation method of amorphous cefmetazole sodium sterile powder and a pharmaceutical composition containing the cefmetazole sodium, which overcomes the defects of poor stability and poor redissolution clarity of cefmetazole sodium for injection in the prior art and provides a new medication choice of cefmetazole sodium. |
| priorityDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.