http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107459522-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-20 |
| filingDate | 2017-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107459522-B |
| titleOfInvention | The preparation method of natural alkaloid Lundurine A-C |
| abstract | The preparation method of natural alkaloid Lundurine A-C is starting material from lactone I, reacts by carbonylalkynylization and generate TMS base lactone II；TMS base lactone II open loop removes TMS group simultaneously and converts to glycol III；Glycol acetyl is melted into ester IV, that is, intermediate compound IV, ester IV alkynes propyl ester selectivity and 5- methoxytryptamine aminating reaction formation propargylamine V, that is, intermediate V under mantoquita catalysis；Ring closure reaction, which is carried out, in neutral heat condition propargylamine V generates lactams VI VI；Aza-octane VII is generated using monovalence gold reagent catalysis lactams VI, Tosylhydrazone XI forms intermediate X II by intramolecular [3+2] cycloaddition-denitrification reaction；The amidocarbonylation alpha-position seleno of XII, oxidation elimination reaction generate Lundurine A；And the amide direct-reduction of intermediate X II generates Lundurine C. |
| priorityDate | 2017-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.