http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107435050-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-18843 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2750-14143 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-864 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
| filingDate | 2017-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107435050-B |
| titleOfInvention | A method of inducing human or animal somatic cells into neural stem cells |
| abstract | The invention discloses a method for inducing human or animal somatic cells into neural stem cells and the use of the neural stem cells obtained by the method. The somatic cells can be induced into neural stem cells (iNSCs) by overexpressing the transcription factor Ptf1a in isolated human or animal somatic cells and culturing them in a medium containing EGF and bFGF. The iNSCs obtained by this method have the ability of self-renewal, can be stably passaged for more than 50 generations, and maintain the original cell characteristics. Cultured in different in vitro differentiation media, iNSCs can efficiently differentiate into neurons, astrocytes, and oligodendrocytes. When iNSCs are injected into animals, the injected cells can be integrated into neural tissues such as retina and brain. The method used in the present invention is simpler, more efficient and safer than previous methods. The iNSCs and further differentiated cells obtained by the method of the present invention can be applied to cell models of neurological diseases, drug screening, stem cell therapy and the like. |
| priorityDate | 2017-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.