http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107434802-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d45bf8dbfff4f55887273981fe95475 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2016-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e60078db6df7df787b5dd56f6e24f54e |
| publicationDate | 2017-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107434802-A |
| titleOfInvention | A kind of preparation method of Esomeprazole sodium |
| abstract | Disclosed by the invention is a kind of preparation method of Esomeprazole sodium, specifically includes following steps：1. into thioether：By the in the mixed solvent heating stirring of the methoxybenzimidazol of 2 sulfydryl of raw material 5 and the methoxy-pyridine hydrochloride of 2 chloromethyl, 3,5 dimethyl 4 in the presence of highly basic；2. aoxidize：Organic base, chiral reagent, oxidant, stirring will be added in above-mentioned Omeprazole thioether and organic solvent, temperature control obtains the reaction solution containing esomeprazole；3. into salt：2) reaction solution in is extracted through ammoniacal liquor, fetching water mutually is acidified, by organic solvent C extraction, be evaporated, flow back, crystallization, produce Esomeprazole sodium；The present invention is easy to operate, environmental pollution is few, high income, cost is low, optical purity of products is high, more suitable for industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111072633-A |
| priorityDate | 2016-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.