abstract |
The present invention relates to compounds of formula I , wherein A1, A2, A3, R1, R2, R3 , R4, R5 , R6 , L , Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzymatic activity. The present invention also relates to processes for preparing these compounds, pharmaceutical compositions containing them, and their use in the treatment of proliferative disorders such as cancer, and other diseases or conditions in which ATX activity is implicated (eg, fibrosis). |